Tag Archive | "dissolution"

Optimizing Design of Experiments for Fluid Bed Coating

Posted on 30 March 2010. Tags: , , ,

Upsher-Smith Laboratories (Minneapolis, Minn.) faced a problem with a fluid bed coating process that produced inconsistent results. Many of the coating parameters interacted with each other, so conventional one-factor-at-a-time (OFAT) experiments were unable to resolve the issue. Sarah Betterman, scientist for Upsher-Smith, used design of experiments (DoE) to determine how the key coating process parameters affect dissolution, the critical response.

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